Encapsulation of Drug‐Loaded Graphene Oxide‐Based Nanocarrier into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer

With the high rate of mortality associated with breast cancer among women, treatment has attracted great deal attention globally. To reduce exposure body organs to cytotoxicity common chemotherapeutic drugs, local co-delivery selected chemotherapeutics emerged as a solution. In this work, an electrospun composite including co-drug-loaded graphene oxide-based nanocarrier is fabricated for anticancer applications. increase dispersion and cellular uptake oxide (GO), first, hydroxyl groups at edges GO are grafted by poly (epichlorohydrin) (PCH) form GO-PCH. Then, end PCH (g) hyperbranched polyglycerol (HPG) leading formation oxygen-rich (GO-PCH-g-HPG). Paclitaxel (PTX) curcumin (Cur) loaded into GO-PCH-g-HPG nanocarrier, encapsulated pullulan nanofibers using electrospinning. SEM, FTIR, UV–Vis characterizations confirmed presence distribution inside nanofibers. The drugs showed sustained release (93 h) from nanocarrier-loaded in neutral pH (7.4). According MTT assay optical microscopy, synergistic effect PTX Cur observed. nanocarrier-encapsulated nanofiber system represents novel tunable drug delivery